Prague is the capital and largest city in the Czech Republic, the 13th largest city in the European Union and the historical capital of Bohemia. Prague is a political, cultural and economic centre of central Europe complete with a rich history. Founded during the Romanesque and flourishing by the Gothic, Renaissance and Baroque eras, Prague was the capital of the Kingdom of Bohemia and the main residence of several Holy Roman Emperors, most notably of Charles IV (r. 1346–1378). Prague is home to a number of well-known cultural attractions, many of which survived the violence and destruction of 20th-century Europe. Main attractions include Prague Castle, Charles Bridge, Old Town Square with the Prague astronomical clock, the Jewish Quarter, Petřín hill and Vyšehrad. Since 1992, the historic center of Prague has been included in the UNESCO list of World Heritage Sites.

Prague has more than ten major museums, along with numerous theaters, galleries, cinemas, and other historical exhibits. An extensive modern public transportation system connects the city. It is home to a wide range of public and private schools, including Charles University in Prague, the oldest university in Central Europe.

The city is traditionally one of the cultural centres of Europe, hosting many cultural events. Some of the significant cultural institutions include the National Theatre (Národní Divadlo) and the Estates Theatre (Stavovské or Tylovo or Nosticovo divadlo), where the premières of Mozart's Don Giovanni and La clemenza di Tito were held. Other major cultural institutions are the Rudolfinum which is home to the Czech Philharmonic Orchestra and the Municipal House which is home to the Prague Symphony Orchestra. The Prague State Opera (Státní opera) performs at the Smetana Theatre.

The city has many world-class museums, including the National Museum (Národní muzeum), the Museum of the Capital City of Prague, the Jewish Museum in Prague, the Alfons Mucha Museum, the African-Prague Museum, the Museum of Decorative Arts in Prague, the Náprstek Museum (Náprstkovo Muzeum), the Josef Sudek Gallery and The Josef Sudek Studio, the National Library and the National Gallery, which manages the largest collection of art in the Czech Republic.

There are hundreds of concert halls, galleries, cinemas and music clubs in the city. It hosts music festivals including the Prague Spring International Music Festival, the Prague Autumn International Music Festival, the Prague International Organ Festival and the Prague International Jazz Festival. Film festivals include the Febiofest, the One World Film Festival and Echoes of the Karlovy Vary International Film Festival. The city also hosts the Prague Writers' Festival, the Prague Folklore Days, Prague Advent Choral Meeting the Summer Shakespeare Festival, the Prague Fringe Festival, the World Roma Festival, as well as the hundreds of Vernissages and fashion shows.

The city has many buildings by renowned architects, including Adolf Loos (Villa Müller), Frank O. Gehry (Dancing House) and Jean Nouvel (Golden Angel).